Has2 expression

1. α-ketoglutarate-JMJD3 axis decreases Has2 expression in mice.

   “We also found that the α-ketoglutarate-JMJD3 axis downregulates Has2 expression.”

   Animalsskeletal muscle

   Early-life NAD⁺ deficiency programs skeletal muscle aging by sustained suppression of hyaluronic acid synthesis beginning in childhood

   Cell reports·28 Jan 2026

1. NADSYN1 increases Has2 expression in mice.

   “Gene expression analysis showed that hyaluronic acid synthase 2 (Has2) was downregulated in both young NADS-knockout mice and aged wild-type mice.”

   Animalsshown by NADS knockoutskeletal muscle

   Early-life NAD⁺ deficiency programs skeletal muscle aging by sustained suppression of hyaluronic acid synthesis beginning in childhood

   Cell reports·28 Jan 2026

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