What does the research say about glutamate accumulation?

Glutamate accumulation

There is 1 paper on glutamate accumulation in aging research: none in people yet, 1 in animals. The newest story, Nov 2, 2026: “Brain enzyme contributes to memory problems after surgery in mice”.

Biomarker

1 paper studies it4 more mention it1 finding

1 new paper in 30 daysSee all 5 papers on glutamate accumulation

Animals1

Interventions

Abdominal surgery

upin mice1

1 study

Abdominal surgery increases glutamate accumulation in mice.
“Abdominal surgery induced male-specific deficits in recognition and spatial memory, reduced hippocampal glymphatic influx, and glutamate accumulation in aged mice.”
Animals
Brain enzyme contributes to memory problems after surgery in mice
Alzheimer's & dementia : the journal of the Alzheimer's AssociationJul 1, 2026

Latest

3 papers in 12 months

Alzheimer's & DementiaJul 10

Brain enzyme contributes to memory problems after surgery in mice

Experiments in mice aged 18–20 months implicated an enzyme in brain support cells in male-specific memory problems during the week after surgery.Experiments in mice aged 18–20 months implicated an enzyme in brain support cells in male-specific memory problems during the week after surgery.

Mouse studyMechanisms

Paper

Frontiers in PharmacologyNov 2

Metformin regulates astrocyte autophagy via the AMPK/mTOR pathway to improve glutamate homeostasis and prevent cognitive impairment induced by cerebral ischemia-reperfusion

Accepted, not yet published: experiments in ratsMetformin

Paper

Cell Communication and SignalingJul 10

Glutamate alters metabolism in human marrow support cells

Experiments in lab-grown human marrow support cells found signs of senescence, a state in which cells stop dividing, and increased collagen deposition after glutamate…Experiments in lab-grown human marrow support cells found signs of senescence, a state in which cells stop dividing, and increased collagen deposition after glutamate exposure.

Human cell studyAmino acid metabolism

Paper

Aging CellDec 29

Increased A1 astrocyte activation-driven hippocampal neural network abnormality mediates delirium-like behavior in aged mice undergoing cardiac surgery

Experiments in miceMechanisms

Paper

Molecular NeurobiologyMay 24

Paraquat as an Environmental Risk Factor in Parkinson's Disease Accelerates Age-Related Degeneration Via Rapid Influx of Extracellular Zn²⁺ into Nigral Dopaminergic Neurons

Experiments in animalsMechanisms

Paper