Glaucoma polygenic risk score

1. Glaucoma polygenic risk score improves glaucoma prediction model AUC in silico (prediction model with age, sex and intraocular pressure) (from 0.63 to 0.82).

   “adding PRS to a prediction model with age, sex and intraocular pressure increased the Area Under the Curve for predicting glaucoma status from 0.63 to 0.82.”

   In silicoprediction model with age, sex and intraocular pressure

   Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestries

   medRxiv·Jan 24, 2026Preprint

1. Glaucoma polygenic risk score predicts glaucoma surgery in humans.

   “The PRS also predicted need for treatment escalation in early glaucoma and both prevalent and incident surgery.”

   Humans

   Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestries

   medRxiv·Jan 24, 2026Preprint

1. Glaucoma polygenic risk score is linked with a higher risk of glaucoma in humans (top 10% PRS individuals relative to remainder) (OR=10.0).

   “top 10% PRS individuals had 10-fold increased risk (OR=10.0) relative to the remainder.”

   Humanstop 10% PRS individuals relative to remainder

   Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestries

   medRxiv·Jan 24, 2026Preprint

More on Glaucoma

1. Glaucoma polygenic risk score is associated with peripapillary retinal nerve fiber layer thickness in humans with increasing age (−0.61 μm per SD of GPRS; 95% CI −0.86 to −0.36).

   “Higher GPRS was associated with thinner global pRNFL”

   Humanswith increasing ageperipapillary retinal nerve fiber layern = 7,844

   The Association of Polygenic Risk Score With Glaucoma and Its Related Traits: Results From Two German Population-Based Studies

   Investigative ophthalmology & visual science·Dec 1, 2025

More on Peripapillary retinal nerve fiber layer thickness

1. Glaucoma polygenic risk score is associated with intraocular pressure in humans (0.54 mm Hg per SD of GPRS; 95% CI 0.48–0.59).

   “Higher GPRS is associated with glaucoma prevalence, higher IOP and thinner pRNFL in two population-based studies in Germany.”

   Humansn = 8,938

   The Association of Polygenic Risk Score With Glaucoma and Its Related Traits: Results From Two German Population-Based Studies

   Investigative ophthalmology & visual science·Dec 1, 2025

More on Intraocular pressure

1. Glaucoma polygenic risk score is associated with glaucoma prevalence in humans (Prevalence ratio 1.84, 95% CI 1.60–2.11).

   “Increased GPRS was significantly associated with increased glaucoma prevalence”

   Humansn = 12,147

   The Association of Polygenic Risk Score With Glaucoma and Its Related Traits: Results From Two German Population-Based Studies

   Investigative ophthalmology & visual science·Dec 1, 2025

More on Glaucoma prevalence