Frequency of productive TRA clonotypes

chronic antigen exposure increases frequency of productive TRA clonotypes in humans.

“Moreover, our data provide evidence of chronic antigen exposure further increasing the frequency of productive TRA sequences.”

Humans

Age-related changes in the human T cell receptor alpha repertoire suggest positive selection of dual-specific T cells

Journal of immunology (Baltimore, Md. : 1950)·4 Aug 2026

T cell maturation stage increases frequency of productive TRA clonotypes in humans.

“The frequency of productive TRA clonotypes increased along the T cell maturation stage and showed a consistent positive correlation with the donor age.”

Humans

Age-related changes in the human T cell receptor alpha repertoire suggest positive selection of dual-specific T cells

Journal of immunology (Baltimore, Md. : 1950)·4 Aug 2026

Age is associated with frequency of productive TRA clonotypes in humans.

“showed a consistent positive correlation with the donor age.”

Humans

Age-related changes in the human T cell receptor alpha repertoire suggest positive selection of dual-specific T cells

Journal of immunology (Baltimore, Md. : 1950)·4 Aug 2026