Fornix volume

1. Fornix volume is associated with cognitive function in humans.

   “MS fornix volume/diffusion metrics correlated with various clinical/cognitive scores.”

   Humansmultiple sclerosis

   High-resolution fluid-suppressed diffusion tractography of the fornix across the healthy lifespan and deviations in multiple sclerosis

   Imaging neuroscience (Cambridge, Mass.)·Mar 30, 2026

1. Multiple sclerosis is associated with fornix volume in humans (-29%).

   “MS fornix volume followed a similar age trend, but remained below controls at all ages and was proportionally reduced (-29%) more than all other brain volumes.”

   Humansmultiple sclerosisn = 42

   High-resolution fluid-suppressed diffusion tractography of the fornix across the healthy lifespan and deviations in multiple sclerosis

   Imaging neuroscience (Cambridge, Mass.)·Mar 30, 2026

More on Multiple sclerosis

1. Chronological age is associated with fornix volume in humans (~1.7x).

   “Control fornix volume increased markedly (~1.7x) from 12 to 33 years and then declined to a similar extent by 65 years”

   Humanshealthy controls

   High-resolution fluid-suppressed diffusion tractography of the fornix across the healthy lifespan and deviations in multiple sclerosis

   Imaging neuroscience (Cambridge, Mass.)·Mar 30, 2026