Excitatory/inhibitory ratio

Healthy aging decreases excitatory/inhibitory ratio in humans.

“along with a reduction in the E/I ratio, suggesting diminished inhibitory and excitatory tone with advancing age”

Humanscalcarine cortexn = 187

Neurochemical changes in GABA+, Glx, and the excitatory/inhibitory ratio in the calcarine cortex with healthy aging

NeuroImage·5 Dec 2025