Epigenetic age acceleration variability

1. Multiple sclerosis is associated with epigenetic age acceleration variability in humans (PhenoAge SD in secondary progressive MS: 12.7, 1.5 times that of controls).

   “This study found that epigenetic age acceleration (EAA) exhibits greater variability in individuals with multiple sclerosis (MS) compared to sex- and age-matched healthy controls (HC).”

   HumansMultiple sclerosis compared with sex- and age-matched healthy controls

   Clocks out of sync: Increased epigenetic aging variability in multiple sclerosis

   Journal of the neurological sciences·30 Mar 2026

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