Genes & Development
A protein network fails to preserve gut cell identity in aging flies
Experiments in adult flies traced how machinery associated with stem cells became active again with age, undermining mature gut cells’ specialized identity.Experiments in adult flies traced how machinery associated with stem cells became active again with age, undermining mature gut cells’ specialized identity.
Fly studyGut and microbiome
Who was studiedAdult Drosophila flies, against young enterocytes
What changedAging gut cells had lower mature-cell gene activity as stem cell-related machinery reactivated, unlike in young cells
The catchCell identity loss was inferred from declining enterocyte gene signatures