Enlarged perivascular spaces in centrum semiovale

1. Enlarged perivascular spaces in centrum semiovale is linked with worse verbal fluency in APOE-ε4 carriers, controlling for other CSVD markers (p < 0.05).

   “among apolipoprotein E (APOE) -ε4 carriers, greater CSO-EPVS load was associated with lower verbal fluency z-score”

   Humansin APOE-ε4 carriers, controlling for other CSVD markersbrain

   Association of enlarged perivascular spaces with cognitive function in dementia-free older adults: A population-based study

   Alzheimer's & dementia (Amsterdam, Netherlands)·Jul 23, 2024

1. Enlarged perivascular spaces in centrum semiovale is associated with neurogranin in amyloid-positive individuals, after adjustment for confounders.

   “Higher levels of p-tau, t-tau, and neurogranin were significantly associated with ePVS in the CS of Aβ positive individuals, after accounting for relevant confounders.”

   Humansin amyloid-positive individuals, after adjustment for confounderscentrum semiovale

   Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum

   Alzheimer's research & therapy·Aug 5, 2021

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1. Enlarged perivascular spaces in centrum semiovale is associated with CSF p-tau in amyloid-positive individuals, after adjustment for confounders.

   “Higher levels of p-tau, t-tau, and neurogranin were significantly associated with ePVS in the CS of Aβ positive individuals, after accounting for relevant confounders.”

   Humansin amyloid-positive individuals, after adjustment for confounderscentrum semiovale

   Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum

   Alzheimer's research & therapy·Aug 5, 2021

More on CSF p-tau