medRxiv
DNA changes in Barrett’s esophagus traced back decades
An observational preprint involving 80 people found that the timing and pace of DNA changes predicted cancer risk better than their extent alone.An observational preprint involving 80 people found that the timing and pace of DNA changes predicted cancer risk better than their extent alone.
Preprint: cohort · 80 peopleMechanisms
Who was studied80 people with Barrett’s esophagus
What changedDNA changes in Barrett’s esophagus typically began accumulating decades before diagnosis, sometimes during childhood
The catchDNA change dates were modeled from single-time-point samples, not observed over decades