Duodenal osmolality

1. Proton-pump inhibitors decrease duodenal osmolality in humans (274 vs. 333 mOsmol/kg).

   “PPIs decrease mean osmolality in older adults (274 vs. 333 mOsmol/kg), in line with previous observations in adults.”

   Humansfasting duodenal contentsduodenum

   Chronological age, proton pump inhibitors in older adults, and diabetes in older adults on physicochemical characteristics of contents of the descending duodenum during fasting: An exploratory study

   European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·25 Feb 2026

More on Proton-pump inhibitors

1. Chronological ageing has no effect on duodenal osmolality in humans.

   “osmolality does not seem to be affected by chronological ageing”

   Humansfasted stateduodenum

   Chronological age, proton pump inhibitors in older adults, and diabetes in older adults on physicochemical characteristics of contents of the descending duodenum during fasting: An exploratory study

   European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·25 Feb 2026