DNA methylation instability

1. DNA methylation instability decreases survival in humans.

   “a shift linked to higher cardiovascular disease risk and lower survival rates”

   Humansnon-cancer cohortsblood

   Blood-based epigenetic instability linked to human aging and disease

   Nature communications·14 Feb 2026

1. DNA methylation instability is associated with clonal burden in humans.

   “methylation pattern disruption in myeloid and lymphoid malignancies, correlating with clonal burden dynamics and mutation frequency throughout leukemia treatment”

   Humansleukemia treatmentblood

   Blood-based epigenetic instability linked to human aging and disease

   Nature communications·14 Feb 2026

More on Clonal burden

1. DNA methylation instability raises the risk of cardiovascular disease in humans.

   “a shift linked to higher cardiovascular disease risk”

   Humansnon-cancer cohortsblood

   Blood-based epigenetic instability linked to human aging and disease

   Nature communications·14 Feb 2026

More on Cardiovascular disease