Diastolic Age

1. Diastolic Age predicts major adverse cardiovascular events in humans (HR 2.30 (95% CI 1.70–3.18)).

   “Over median follow-up of 4.2 years, it independently predicted MACE (HR 2.30, 95% CI 1.70–3.18)”

   HumansMedian follow-up of 4.2 years

   Diastolic Age: A Cardiac Biological Clock Derived from Echocardiography and the PREVENT Heart Failure Risk Score

   medRxiv·17 Apr 2026Preprint

More on Major adverse cardiovascular events

1. Diastolic Age is associated with Horvath clock in humans (r=0.41).

   “While correlated with the Levine (r=0.76) and Horvath (r=0.41) epigenetic clocks”

   Humans

   Diastolic Age: A Cardiac Biological Clock Derived from Echocardiography and the PREVENT Heart Failure Risk Score

   medRxiv·17 Apr 2026Preprint

More on Horvath clock

1. Diastolic Age is associated with Levine epigenetic clock in humans (r=0.76).

   “While correlated with the Levine (r=0.76) and Horvath (r=0.41) epigenetic clocks”

   Humans

   Diastolic Age: A Cardiac Biological Clock Derived from Echocardiography and the PREVENT Heart Failure Risk Score

   medRxiv·17 Apr 2026Preprint

More on Levine epigenetic clock

1. Diastolic Age predicts left ventricular diastolic dysfunction in humans (AUC 0.89 (95% CI 0.87–0.92)).

   “It increased progressively across grades of diastolic dysfunction and discriminated LVDD with an AUC of 0.89 (95% CI 0.87–0.92)”

   HumansASE-defined LV diastolic dysfunctionleft ventricle

   Diastolic Age: A Cardiac Biological Clock Derived from Echocardiography and the PREVENT Heart Failure Risk Score

   medRxiv·17 Apr 2026Preprint

More on Left ventricular diastolic dysfunction

1. Diastolic Age is associated with chronological age in humans (r=0.78; external validation: WASE r=0.76, Stanford r=0.82).

   “Diastolic Age correlated strongly with chronological age (r=0.78) with robust external validation (WASE r=0.76; Stanford r=0.82; calibration slopes ≈1.0).”

   Humansleft ventricle54% femalesn = 1,952

   Diastolic Age: A Cardiac Biological Clock Derived from Echocardiography and the PREVENT Heart Failure Risk Score

   medRxiv·17 Apr 2026Preprint