Deep spatial white matter hyperintensity pattern: aging research evidence

Effects

1

Baseline cognitive performance

no changein humans1

1 study

Deep spatial white matter hyperintensity pattern has no effect on baseline cognitive performance in humans.
“showed no cross-sectional association at baseline”
Humanscross-sectional analysis at baselinecorpus callosum and anterior corona radiatan = 1,667
Brain scan pattern linked to later decline in thinking skills
bioRxivOct 20, 2026Preprint

Associations

1

Cognitive function

downin humans1

1 study

Deep spatial white matter hyperintensity pattern is associated with cognitive function in humans.
“A deep spatial pattern of WMH loading on the corpus callosum and anterior corona radiata was associated with subsequent cognitive decline”
Humansindependent of total lesion burdencorpus callosum and anterior corona radiataapproximately six yearsn = 1,667
Brain scan pattern linked to later decline in thinking skills
bioRxivOct 20, 2026Preprint

Latest

1 paper in 12 months

bioRxivOct 20

Brain scan pattern linked to later decline in thinking skills

An observational study of 1,667 older adults over approximately six years linked a pattern of bright areas on brain scans to declining thinking skills.An observational study of 1,667 older adults over approximately six years linked a pattern of bright areas on brain scans to declining thinking skills.

Preprint: cohort · 1,667 peoplePopulations

Paper

Deep spatial white matter hyperintensity pattern

Effects

Associations

Latest

Brain scan pattern linked to later decline in thinking skills

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