medRxiv
Spinal fluid protein patterns recur in early Parkinson’s
The observational preprint compared healthy controls, people with possible early signs and people with untreated Parkinson’s in independent cohorts of 721 and 974…The observational preprint compared healthy controls, people with possible early signs and people with untreated Parkinson’s in independent cohorts of 721 and 974 participants.
Preprint: cross-sectional studyParkinson's disease
Who was studiedControls and people with prodromal or manifest Parkinson's
What changedSpinal fluid levels of 15 proteins differed consistently between early manifest Parkinson's and healthy controls across independent cohorts
The catchDisease-stage comparisons measured differences between people, not protein changes within individuals over time