Papers on CYP3A

8 papers

Thursday, January 15

BMC Pharmacology & ToxicologyJan 15

Impact of aging on the pharmacokinetic profile of everolimus in male mice

Experiments in micemTOR inhibitors

Wednesday, August 21

Clinical Pharmacology and TherapeuticsAug 21

Aging-Related CYP3A Functional Changes in Chinese Older Patients: New Findings from Model-Based Assessment of Amlodipine

Cohort study of 69 peopleMechanisms

Wednesday, October 18

Pharmacological ReportsOct 18

The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats

Experiments in ratsMechanisms

Tuesday, October 5

Frontiers in PharmacologyOct 5

Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach

Non-randomized trial in 20 peopleKidney

Monday, June 28

Drug Metabolism and DispositionJun 28

Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor κ-B Pathway in Mouse Nonalcoholic Fatty Liver Disease

Experiments in miceInterventions

Friday, January 1

Voprosy PitaniiaJan 1

Influence of the L-carnitine and resveratrol complex on physiological, biochemical and morphological indicators of normal and obese rats

Experiments in animalsInterventions

Thursday, May 31

BMJ OpenMay 31

Impact of body weight, low energy diet and gastric bypass on drug bioavailability, cardiovascular risk factors and metabolic biomarkers: protocol for an open, non-randomised, three-armed single centre study (COCKTAIL)

Interventions

Saturday, July 9

Biomedical ChromatographyJul 9

In vitro metabolism of specific CYP2D and CYP3A opioid substrates using rat liver S9 fractions and mass spectrometry reveal a severe metabolic impairment with increasing age

Experiments in animalsMechanisms