CX3CR1+Ly6C+ macrophages

1. Quadrivalent inactivated influenza vaccine increases CX3CR1+Ly6C+ macrophages in mice (intramuscular injection with AddaVax).

   “intramuscular injection of a quadrivalent inactivated influenza vaccine (QIV) with AddaVax triggers a muscle regenerative-like immune response, increasing CX3CR1+Ly6C+ macrophages in muscle and draining lymph nodes”

   Animalsintramuscular injection with AddaVaxmuscle and draining lymph nodesfour days

   Muscle macrophage regenerative response after squalene-adjuvanted influenza vaccination is associated with type II-skewed response and is reduced with age

   NPJ vaccines·Jul 4, 2026

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1. Addavax increases CX3CR1+Ly6C+ macrophages in mice.

   “AddaVax triggers a muscle regenerative-like immune response, increasing CX3CR1+Ly6C+ macrophages in muscle and draining lymph nodes within four days.”

   Animalsskeletal musclefour days

   Muscle macrophage regenerative response after squalene-adjuvanted influenza vaccination drives Th2-skewed response and is reduced with age

   Research Square·Mar 6, 2026Preprint

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1. Aged mice decreases CX3CR1+Ly6C+ macrophages in mice.

   “In aged mice, the macrophage response and type II skewing are diminished.”

   Animals

   Muscle macrophage regenerative response after squalene-adjuvanted influenza vaccination is associated with type II-skewed response and is reduced with age

   NPJ vaccines·Jul 4, 2026

More on Aged mice