AHA Scientific Sessions 2026 Abstract
Heart, kidney and metabolic burden linked to later heart risk
An observational analysis of 2,968 CARDIA participants and 4,294 MESA participants linked accumulated burden to unfavorable heart structure and function and higher…An observational analysis of 2,968 CARDIA participants and 4,294 MESA participants linked accumulated burden to unfavorable heart structure and function and higher cardiovascular event risk.

Cohort studyCardiovascular-kidney-metabolic diseases
Who was studiedParticipants in young and mid-to-late adulthood, 8.9 and 8.7 years
What changedRisk of major cardiovascular events was higher with greater cumulative burden: hazard ratio 2.35 in CARDIA and 1.71 in MESA
The catchWhether reducing accumulated burden lowers cardiovascular risk was not measured