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Cumulative CKM-years

There is 1 paper on cumulative CKM-years in aging research: 1 observational study in people. The newest story, Nov 7, 2026: “Heart, kidney and metabolic burden linked to later heart risk”.

Biomarker

1 paper studies it2 findings

1 new paper in 30 daysSee all 1 papers on cumulative CKM-years

“Higher cumulative CKM-years were associated with a consistent adverse remodeling phenotype in both cohorts”
Cumulative Cardiovascular-Kidney-Metabolic Burden, Adverse Cardiac Remodeling and Clinical Events: A Life-Course Analysis of MESA and CARDIAAHA Scientific Sessions 2026 abstract2026doi:10.1161/circ.154.suppl_1.11622
  • Humans1

Associations

2

Major adverse cardiovascular events

upin humans1HR 2.35

1 study

  1. Cumulative CKM-years are associated with major adverse cardiovascular events in humans (CARDIA) (HR 2.35 [1.79-3.09] per 1-SD increment).

    “each 1-SD increment in CKM-years was associated with a higher adjusted risk of MACE (CARDIA: HR 2.35 [1.79-3.09]; MESA: HR 1.71 [1.40-2.09]).”

    HumansCARDIAeach 1-SD incrementmedian post-landmark follow-up 8.9 years55% womensn = 2,968

    Heart, kidney and metabolic burden linked to later heart risk

    AHA Scientific Sessions 2026 abstract

More on Major adverse cardiovascular events

Adverse cardiac remodeling

upin humans1

1 study

  1. Cumulative CKM-years are associated with adverse cardiac remodeling in humans (CARDIA and MESA).

    “Higher cumulative CKM-years were associated with a consistent adverse remodeling phenotype in both cohorts”

    HumansCARDIA and MESAheart

    Heart, kidney and metabolic burden linked to later heart risk

    AHA Scientific Sessions 2026 abstract

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AHA Scientific Sessions 2026 Abstract

Heart, kidney and metabolic burden linked to later heart risk

An observational analysis of 2,968 CARDIA participants and 4,294 MESA participants linked accumulated burden to unfavorable heart structure and function and higher…An observational analysis of 2,968 CARDIA participants and 4,294 MESA participants linked accumulated burden to unfavorable heart structure and function and higher cardiovascular event risk.

Cohort studyCardiovascular-kidney-metabolic diseases
Paper

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