There are 2 papers on CSF t-tau in aging research: 2 observational studies in people. The newest story, Oct 4, 2026: “High neutrophil-to-lymphocyte ratio predicts cognitive decline”.
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“higher levels of plasma ApoB were also found associated with decreases in CSF t-tau (p = 0.0224), p-tau (p = 0.0086) and Aβ40 (p = 0.0297) in the SCD subgroup”
Apolipoprotein B
downin humans1
Apolipoprotein B is associated with CSF t-tau in humans (SCD subgroup) (p = 0.0224 (t-tau); p = 0.0086 (p-tau); p = 0.0297 (Aβ40)).
“higher levels of plasma ApoB were also found associated with decreases in CSF t-tau (p = 0.0224), p-tau (p = 0.0086) and Aβ40 (p = 0.0297) in the SCD subgroup”
HumansSCD subgroup
Preprint
Eigenvector centrality in left lingual gyrus
downin humans1
Eigenvector centrality in left lingual gyrus is associated with CSF t-tau in APOE ε4 carriers (r = -0.57).
“left LG EC value correlated with Rey Auditory Verbal Learning Test total learning (RAVLT, r = 0.57, p < 0.05) and t-tau level (r = -0.57, p < 0.05)”
Humansin APOE ε4 carriersleft lingual gyrusn = 13
Brain imaging and behavior
During five years of follow-up, 42.55% of older adults with high ratios progressed to mild cognitive impairment or dementia compared with 30.82% with normal ratios.During five years of follow-up, 42.55% of older adults with high ratios progressed to mild cognitive impairment or dementia compared with 30.82% with normal ratios.