Cortical capillary density

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GeroScience20 Aug

Endothelial IGF-1/IGF-1R signaling supports young-blood-induced restoration of blood-brain barrier integrity and microvascular architecture in aged mice: evidence from the heterochronic parabiosis model

Experiments in miceInsulin/IGF-1 signalling

GeroScience10 May

Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged mouse brain

Experiments in miceInterventions

Microcirculation12 Dec

Endothelial deficiency of insulin-like growth factor-1 receptor leads to blood-brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype

Experiments in animalsMechanisms