Conversion of CG dinucleotides from mC to hmC

Postnatal development increases conversion of CG dinucleotides from mC to hmC in humans (up to half).

“Up to half of all CG dinucleotides convert from mC to hmC in a gradual process extending throughout the first decade of life”

Humansprefrontal cortex

Postnatal conversion of methylcytosine to hydroxymethylcytosine reconfigures the human neuronal epigenome

bioRxiv : the preprint server for biology·19 Feb 2026Preprint