Asymmetric enrichment of hmC on the sense strand of actively transcribed genes

Age increases asymmetric enrichment of hmC on the sense strand of actively transcribed genes in humans.

“Asymmetric enrichment of hmC on the sense strand of actively transcribed genes increases in a linear, clock-like fashion throughout the lifespan”

Humansprefrontal cortex

Postnatal conversion of methylcytosine to hydroxymethylcytosine reconfigures the human neuronal epigenome

bioRxiv : the preprint server for biology·19 Feb 2026Preprint