Clinical frailty

Biomarker

1 paper

  • Human trial1

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medRxiv

Routine data helped target frailty checks in chronic disease

In the model’s validation sample, screening the highest-risk 20% identified 55.6% of frailty cases, a 2.78-fold improvement over random screening.In the model’s validation sample, screening the highest-risk 20% identified 55.6% of frailty cases, a 2.78-fold improvement over random screening.

Preprint: cross-sectional study of 281,729 peopleBiomarkers
Research Square

Model predicted frailty risk in older emergency patients

The model achieved a discrimination score of 0.940 in 143 patients set aside for testing, in a retrospective study of older emergency patients.The model achieved a discrimination score of 0.940 in 143 patients set aside for testing, in a retrospective study of older emergency patients.

Preprint: cohort study of 22,670 peopleBiomarkers
Journal of the American Medical Directors Association

Comorbidity link to hospital disability fades with frailty

Comorbidity was linked to hospital disability in nonfrail patients (OR 1.44), but the association attenuated with mild frailty (OR 1.11) and disappeared in frail adults…Comorbidity was linked to hospital disability in nonfrail patients (OR 1.44), but the association attenuated with mild frailty (OR 1.11) and disappeared in frail adults (OR 0.98).

Cohort study of 1,299 peoplePopulations