Circulating CD28null T cells

Frailty is associated with circulating CD28null T cells in humans (CD8+ fraction: 47% vs 29%; CD4+ fraction: 4% vs 1%).

“CD28null T cells were considerably higher (p<0.05) in the frail compared to the robust non-frail group”

Humansfrail compared with robust non-frail adultswhole blood

Circulating Angiogenic and Senescent T Lymphocytes in Ageing and Frailty

The Journal of frailty & aging·1 Jan 2024