Cdkn2a protein expression

1. Polyploidy is associated with Cdkn2a protein expression in mouse cells (3 of 4 independently-derived cell lines).

   “Following crisis and establishment, three of four independently-derived cell lines became polyploid and expressed higher levels of functional p16INK4a.”

   Cellsfunctional p16INK4a in established cell lines following crisismouse embryo fibroblastn = 4

   Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging

   Oncogene·10 Jul 1997

1. Cellular senescence is associated with Cdkn2a protein expression in mouse cells.

   “The levels of p16INK4a and p18INK4c, but not p15INK4b or p19INK4d, further increased as MEFs approached senescence.”

   Cellsp16INK4a protein; MEFs approaching senescencemouse embryo fibroblast

   Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging

   Oncogene·10 Jul 1997

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