Cdkn2a/b

1 paper

Animals1

Funding

1 grant since 2021

National Institute on AgingUS$1.2m

Comprehensive functional genomic analysis of the multi-disease associated CDKN2A/B locus
National Institute on AgingUniversity of Pittsburgh at PittsburghUS$617.3k2021–2026

Latest

3 in 12 months

FigshareFeb 26

The MHC/Complement-Driven Pruning-to-Plaque Cascade: Genomic Evidence for Immune-Mediated Acceleration of Atherosclerosis in Schizophrenia

Preprint: computational studyComplement system

ZenodoFeb 8

From Pruning to Plaque: Schizophrenia Genetics Accelerates Vascular Pathology via Peripheral Immune Extension

Preprint: computational studyImmune response

Aging CellNov 11

PCBP2 Regulates p16INK4a-Dependent Cellular Senescence in Response to Iron

Experiments in human cellsCellular senescence

Research SquareAug 6

SOX17 Regulates Nestin/p16INK4a Axis to Mitigate Endothelial Senescence in Pulmonary Arterial Hypertension

Preprint: experiments in ratsCellular senescence

TheranosticsAug 4

Disrupted macrophage metabolic adaptation and function drive senescence-induced decline in vertebrate regeneration

Experiments in zebrafishOxidative phosphorylation

AgingJun 30

Cathepsin L induces cellular senescence by upregulating CUX1 and p16INK4a

Experiments in human cellsCellular senescence

Aging CellJan 17

Protein phosphatase 2A activators reverse age-related behavioral changes by targeting neural cell senescence

Experiments in zebrafishInterventions

Aging CellJan 13

SATB2, coordinated with CUX1, regulates IL-1β-induced senescence-like phenotype in endothelial cells by fine-tuning the atherosclerosis-associated p16INK4a expression

Experiments in human cellsCellular senescence

Nature AgingFeb 1

Post-GWAS functional analysis identifies CUX1 as a regulator of p16INK4a and cellular senescence

Experiments in cellsMechanisms

Nucleic Acids ResearchOct 12

Coupling high-throughput mapping with proteomics analysis delineates cis-regulatory elements at high resolution

Experiments in cellsMechanisms