ESC Congress 2026 Abstract
Deleting an immune-cell receptor reduces fat inflammation in mice
In male and female mice studied across aging, lacking the mineralocorticoid receptor in macrophages prevented inflammatory cell expansion and improved fat tissue…In male and female mice studied across aging, lacking the mineralocorticoid receptor in macrophages prevented inflammatory cell expansion and improved fat tissue remodeling.
Mouse studyInflammation
Who was studiedMale and female mice, against mice with the receptor
What changedMice lacking the receptor in macrophages had lower inflammatory activation of fat cells than mice with the receptor
The catchFat inflammation was measured; cardiovascular and metabolic function were not measured