CCR7+ CD4 naive T cell abundance

CCR7+ CD4 naive T cell abundance is associated with poor response to neoadjuvant chemoimmunotherapy in humans.

“Our findings associate poor response with reduced levels of CCR7 + CD4 Naïve T cells and CD27 + Memory B cells”

Human trialCancer patients undergoing neoadjuvant chemoimmunotherapy; lower cell levelsn = 51

Reversing Immunosenescence with Senolytics to Enhance Tumor Immunotherapy

medRxiv·15 Oct 2024Preprint