CardioMetAge

1. Caloric restriction decreases CardioMetAge in humans (0.92 years (95% CI: 0.27 to 1.57)).

   “Additionally, two-year caloric restriction slowed the progression of CardioMetAge by 0.92 years (95% CI: 0.27 to 1.57) compared to the ad libitum group.”

   Human trialcompared to the ad libitum group2 years

   CardioMetAge: A Practical Clinical Aging Clock for Predicting Cardiometabolic Mortality and Morbidity · GSA 2025 abstract · 31 Dec 2025

Caloric restriction →