Cardiac age gap

1. Cardiac age gap raises the risk of cardiovascular disease in humans (adjusted HR 2.92 (95% CI: 2.13, 3.99)).

   “Extreme cardiac aging showed strongest CVD risk association (adjusted HR: 2.92, 95% CI: 2.13, 3.99; P < 0.001)”

   Humansdiabetes

   Proteomics-derived organ-specific aging clusters predict macrovascular and microvascular complications in diabetes

   Cardiovascular diabetology·15 Feb 2026

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1. Social determinants of health predicts cardiac age gap in humans (β= -0.197; 95% CI, -0.2 to -0.18; P<.001).

   “SDoH had the highest contribution to predict age gap in the total population (β= -0.197; 95% CI, -0.2 to -0.18; P<.001)”

   Humansn = 280,323

   Interplay of Social Determinants of Health and Traditional Risk Factors in Predicting Cardiac Aging

   Mayo Clinic proceedings·27 Oct 2025

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