The Impact of Brain Age versus Chronological Age on Cognitive Fatigue: Novel Metrics and New Insights

Abstract

Fatigue impacts 22% of the general population. Yet, our understanding of chronological age and fatigue is mixed, suggesting other more novel age- and fatigue-related metrics, such as brain predicted age difference (brain-PAD; i.e., a measure of accelerated/decelerated brain aging) and Signal Detection Theory (SDT; i.e.