Brain Communications
Brain-derived tau tests better flag Alzheimer’s-linked protein
An observational study compared spinal-fluid tests in 1,098 people and blood tests in 925, finding better detection with brain-derived tau tests, with one spinal-fluid…An observational study compared spinal-fluid tests in 1,098 people and blood tests in 925, finding better detection with brain-derived tau tests, with one spinal-fluid exception.
Cross-sectional · 925 peopleAlzheimer's disease
Who was studied925 cognitively unimpaired and cognitively impaired participants
What changedBlood-test accuracy for detecting amyloid was higher with brain-derived tau: area under the curve 91.9 versus 89.7 with conventional tau
The catchFreeze-thaw cycles could alter protein stability and assay signals