Aging Cell
Immune cells may link aging and osteoporosis in humans
An observational analysis of 278,164 UK Biobank participants and analyses of human genetic data linked aging and osteoporosis-related traits in both directions.An observational analysis of 278,164 UK Biobank participants and analyses of human genetic data linked aging and osteoporosis-related traits in both directions.
Computational studyBones and joints
Who was studiedHuman participants and bone marrow cells
What changedMacrophages were linked to both aging and bone density; human validation linked macrophages most strongly to aging
The catchMacrophage associations relied on cell-population averages rather than individual-cell gene expression