Blood pressure complexity
3 papers study it9 findings
- Humans3
Effects
1Frailty
mediatesin humans1
1 study
Frailty
mediatesin humans1
Blood pressure complexity mediates frailty in humans (indirect effects >0.28, mediated proportion >=47%).
“Beat-to-beat SBP and DBP complexity mediated the association between arterial stiffness and frailty (indirect effects >0.28), accounting for at least 47% of its total effects on frailty”
Humansassociation between arterial stiffness and frailtyn = 350
The journals of gerontology. Series A, Biological sciences and medical sciencesFeb 11, 2022
Upstream
2Hypertension
downin humans2
2 studies
Hypertension
downin humans2
Hypertension decreases blood pressure complexity in humans (p < 0.0005).
“SBP and DBP complexity was greatest in normotensive participants, lower in those with controlled-HTN, and lowest in those in uncontrolled-HTN (p < 0.0005).”
Humansolder adultsn = 392
Aging cellAug 24, 2023
Hypertension decreases blood pressure complexity in humans (P<0.001).
“BP complexity was inversely correlated with BPV coefficient of variation (P<0.001) and was similarly reduced in patients with hypertension or diabetes (P<0.001).”
Humansadjusted for age, sex, and cardiovascular risk factorsn = 908
Journal of the American Heart AssociationJan 19, 2022
Age
downin humans1
1 study
Age
downin humans1
age decreases blood pressure complexity in humans (quintile 1: 15.1 [14.0-16.1] versus quintile 5: 13.8 [12.4-15.1]).
“BP complexity fell systematically across age quintiles (quintile 1: 15.1 [14.0-16.1] versus quintile 5: 13.8 [12.4-15.1])”
Humanspatients with transient ischemic attack or minor stroken = 908
Journal of the American Heart AssociationJan 19, 2022
Associations
5Endothelial function
upin humans1
1 study
Endothelial function
upin humans1
Blood pressure complexity is associated with endothelial function in humans (β = 0.17-0.22, p < 0.01).
“worse endothelial function (β = 0.17-0.22, p < 0.01)”
Humansolder adultsn = 392
Aging cellAug 24, 2023
Arterial stiffness
downin humans1
1 study
Arterial stiffness
downin humans1
Blood pressure complexity is associated with arterial stiffness in humans (β = -0.35 to -0.18, p < 0.01).
“greater arterial stiffness (β = -0.35 to -0.18, p < 0.01)”
Humansolder adultsn = 392
Aging cellAug 24, 2023
Orthostatic blood pressure decrease
upin humans1
1 study
Orthostatic blood pressure decrease
upin humans1
Blood pressure complexity is associated with orthostatic blood pressure decrease in humans (β = -0.33 to -0.19, p < 0.01).
“Lower SBP and DBP complexity correlated with greater lying-to-standing decrease in SBP and DBP level (β = -0.33 to -0.19, p < 0.01)”
Humansolder adultsn = 392
Aging cellAug 24, 2023
Arterial stiffness
downin humans1
1 study
Arterial stiffness
downin humans1
Arterial stiffness is associated with blood pressure complexity in humans (β < -0.42, p < .001).
“Greater arterial stiffness was associated with lower BP complexity (β < -0.42, p < .001).”
Humansn = 350
The journals of gerontology. Series A, Biological sciences and medical sciencesFeb 11, 2022
Pulse wave velocity
downin humans1
1 study
Pulse wave velocity
downin humans1
Blood pressure complexity is associated with pulse wave velocity in humans (r = -0.21, adjusted -0.07, P<0.05).
“correlated with markers of autonomic dysfunction (heart rate variability SD of R-R intervals: r = 0.20; BRS low frequency: 0.19; BRS high frequency: 0.26) and arterial stiffness (pulse wave velocity: -0.21”
Humansadjusted for clinical variablesn = 908
Journal of the American Heart AssociationJan 19, 2022