2 papers4 findings
Recall score
downin humans1
Blood manganese is associated with recall score in humans (β = -0.047, 95% CI -0.064 to -0.030 per IQR increase).
“recall ( β = -0.047, 95% CI: -0.064, -0.030)”
HumansChinese elderly individuals; fully covariate-adjusted analysisPer interquartile range increase in blood manganeseAverage follow-up of 4.00 yearsn = 6,868
Higher blood manganese is linked to cognitive impairment
Biomedical and environmental sciences : BES20 Sep 2026
Naming score
downin humans1
Blood manganese is associated with naming score in humans (β = -0.043, 95% CI -0.070 to -0.015 per IQR increase).
“with the strongest associations observed for naming ( β = -0.043, 95% CI: -0.070, -0.015)”
HumansChinese elderly individuals; fully covariate-adjusted analysisPer interquartile range increase in blood manganeseAverage follow-up of 4.00 yearsn = 6,868
Higher blood manganese is linked to cognitive impairment
Biomedical and environmental sciences : BES20 Sep 2026
Mini-Mental State Examination score
downin humans1
Blood manganese is associated with mini-Mental State Examination score in humans (β = -0.033, 95% CI -0.048 to -0.018 per IQR increase).
“were significantly associated with greater declines in MMSE score ( β = -0.033, 95% confidence interval [ CI]: -0.048, -0.018)”
HumansChinese elderly individuals; fully covariate-adjusted analysisPer interquartile range increase in blood manganeseAverage follow-up of 4.00 yearsn = 6,868
Higher blood manganese is linked to cognitive impairment
Biomedical and environmental sciences : BES20 Sep 2026
Cognitive impairment
upin humans1HR 1.131
Blood manganese is associated with cognitive impairment in humans (HR 1.131, 95% CI 1.051–1.217 per IQR increase).
“The risk of cognitive impairment was 13.1% higher for each IQR increase in blood Mn ( HR = 1.131, 95% CI: 1.051, 1.217).”
HumansChinese elderly individuals; covariate-adjusted analysisbloodPer interquartile range increase in blood manganeseAverage follow-up of 4.00 yearsn = 6,868
Higher blood manganese is linked to cognitive impairment
Biomedical and environmental sciences : BES20 Sep 2026
Older adults in the highest quarter of blood manganese levels had a 28.5% greater risk of cognitive impairment than those in the lowest quarter.Older adults in the highest quarter of blood manganese levels had a 28.5% greater risk of cognitive impairment than those in the lowest quarter.