1 paper3 findings
Mortality
upin humans1HR 1.17
Ascending aortic calcification is associated with mortality in humans (Adjusted HR 1.17 per standard deviation (95% CI 1.04-1.32)).
“all-cause mortality (adjusted HR 1.17, 95% CI 1.04-1.32; p=0.009)”
HumansStress total perfusion deficit <5%, myocardial flow reserve >2 and coronary artery calcium 0; adjusted for clinical confoundersMedian follow-up 52 monthsn = 3,580
Main artery calcium linked to risk despite normal heart scans
medRxiv12 Oct 2026Preprint
Heart failure admission
upin humans1HR 1.3
Ascending aortic calcification is associated with heart failure admission in humans (Adjusted HR 1.30 per standard deviation (95% CI 1.10-1.55)).
“heart failure admission (adjusted HR 1.30, 95% CI 1.10-1.55; p=0.003)”
HumansStress total perfusion deficit <5%, myocardial flow reserve >2 and coronary artery calcium 0; adjusted for clinical confoundersMedian follow-up 52 monthsn = 3,580
Main artery calcium linked to risk despite normal heart scans
medRxiv12 Oct 2026Preprint
Cardiovascular death, myocardial infarction or heart failure admission
upin humans1HR 1.24
Ascending aortic calcification is associated with cardiovascular death, myocardial infarction or heart failure admission in humans (Adjusted HR 1.24 per standard deviation (95% CI 1.09-1.40)).
“Per standard deviation, AAC was independently associated with the primary endpoint (adjusted HR 1.24, 95% CI 1.09-1.40; p<0.001)”
HumansStress total perfusion deficit <5%, myocardial flow reserve >2 and coronary artery calcium 0; adjusted for clinical confoundersMedian follow-up 52 monthsn = 3,580
Main artery calcium linked to risk despite normal heart scans
medRxiv12 Oct 2026Preprint
Higher calcium in the main artery was linked to cardiovascular death, heart attack or heart failure admission in 3,580 patients followed for a median 52 months.Higher calcium in the main artery was linked to cardiovascular death, heart attack or heart failure admission in 3,580 patients followed for a median 52 months.