Antigen-specific polyfunctional CD4+ T cells

1. AS01-ADJUVANTED recombinant zoster vaccine increases antigen-specific polyfunctional CD4+ T cells in humans.

   “RZV elicited robust antibody production, antigen-specific polyfunctional CD4+ T cell responses, and IFN-γ from PBMCs in both age groups”

   Human trialyoung and older adults

   Age-related differences in immune responses to inactivated influenza and adjuvanted recombinant herpes zoster vaccines

   JCI insight·Jun 2, 2026

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