Antagonistic anterior insula–ventromedial prefrontal cortex resting-state functional connectivity

Antagonistic anterior insula–ventromedial prefrontal cortex resting-state functional connectivity predicts long-term smoking behavior in humans.

“baseline enhanced antagonistic RSFC between anterior insula and vmPFC predicted long-term smoking reduction”

HumansIndependent UK Biobank replication sample of cognitively normal older adults who smoked cigarettes at baselineAnterior insula and ventromedial prefrontal cortexMean 5.2 years, range 3–7 years73 womensn = 118

Ventromedial frontoinsular connectivity is associated with long-term smoking behavior change in aging

Imaging neuroscience (Cambridge, Mass.)·May 9, 2024

Antagonistic anterior insula–ventromedial prefrontal cortex resting-state functional connectivity is associated with long-term smoking behavior in humans.

“reduced long-term smoking behavior was associated with enhanced antagonistic RSFC between bilateral anterior insula (aINS) and ventromedial prefrontal cortex (vmPFC).”

HumansCognitively unimpaired baseline cigarette smokers with a first-degree family history of Alzheimer's diseaseBilateral anterior insula and ventromedial prefrontal cortexMean 2.7 years, range 8 months–4 years18 womensn = 23

Ventromedial frontoinsular connectivity is associated with long-term smoking behavior change in aging

Imaging neuroscience (Cambridge, Mass.)·May 9, 2024