Ampd3+ pro-atrophy type IIb myonucleus abundance

Older age is associated with Ampd3+ pro-atrophy type IIb myonucleus abundance in mice.

“our analyses reveal an age-enriched pro-atrophy subpopulation of type IIb myonuclei marked by increased chromatin accessibility at the Ampd3 locus.”

Animalsskeletal musclemales

A single-nucleus chromatin accessibility atlas reveals epigenetic dynamics in aging mouse skeletal muscle

The FEBS journal·3 Aug 2026