Advanced proteomic ageing

1. Antiretroviral therapy decreases advanced proteomic ageing in humans (mean difference of 5.99 years (95% CI 4.25, 7.72), p = 0.0001).

   “participants showed significantly higher proteomic age during untreated HIV infection than during suppressive ART, with a mean difference of 5.99 years (95% CI 4.25, 7.72), p = 0.0001.”

   Humanscomparing untreated HIV infection vs suppressive ARTplasma>17 years study spann = 80

   A Plasma Proteomic Ageing Clock Reflects Advanced Ageing in People with Untreated HIV and its Reduction Under Antiretroviral Therapy

   medRxiv·26 Mar 2026Preprint

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1. HIV infection increases advanced proteomic ageing in humans.

   “ART was associated with a marked reduction in proteomic advanced ageing. Although proteomic age remained higher than chronological age at all time points, linear interpolation of per-participant advanced ageing showed progressive normalisation”

   Humansuntreated HIV infectionplasman = 80

   A Plasma Proteomic Ageing Clock Reflects Advanced Ageing in People with Untreated HIV and its Reduction Under Antiretroviral Therapy

   medRxiv·26 Mar 2026Preprint

More on HIV infection