[18F]nifene binding
Biomarker1 paper3 findings
- Humans1
Upstream
2Alzheimer's disease
downin human cells1−38% decrease
1 study
Alzheimer's disease
downin human cells1−38% decrease
Alzheimer's disease decreases [18F]nifene binding in human cells (38% decrease).
Cellsbrain gray matter
Down syndrome postmortem brains exhibit reduction in [ ¹⁸ F]nifene binding to α4β2* nicotinic acetylcholinergic receptors · bioRxiv : the preprint server for biology · 15 Sep 2026 · Preprint
Down syndrome
downin human cells1−43% decrease
1 study
Down syndrome
downin human cells1−43% decrease
Down syndrome decreases [18F]nifene binding in human cells (43% decrease).
Cellsbrain gray matter
Down syndrome postmortem brains exhibit reduction in [ ¹⁸ F]nifene binding to α4β2* nicotinic acetylcholinergic receptors · bioRxiv : the preprint server for biology · 15 Sep 2026 · Preprint
Associations
1[125I]IBETA binding
upin human cells1
1 study
[125I]IBETA binding
upin human cells1
[18F]nifene binding is associated with [125I]IBETA binding in human cells.
Cellsin DSAD
Down syndrome postmortem brains exhibit reduction in [ ¹⁸ F]nifene binding to α4β2* nicotinic acetylcholinergic receptors · bioRxiv : the preprint server for biology · 15 Sep 2026 · Preprint