Jolien M. Schaeverbeke

Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains

Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who…Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.