Craig N. Morrell

Elevated TNFα induces hyperreactive platelets by reprogramming hematopoietic stem cells in mice

The inflammatory cytokine acts directly on stem cells rather than mature megakaryocytes, driving myeloid biasing and thromboinflammation through a…The inflammatory cytokine acts directly on stem cells rather than mature megakaryocytes, driving myeloid biasing and thromboinflammation through a persistent transcriptional program.