Toshiro Fujita
The University of Tokyo1 paperORCID 0000-0001-9141-7060
Papers
Acta PhysiologicaAnimals
Klotho deficiency disrupts potassium balance in mice
In Klotho-deficient mice, renal mTORC1 activation suppressed potassium channel ROMK1 to cause hyperkalemia, which rapamycin or Klotho supplementation…In Klotho-deficient mice, renal mTORC1 activation suppressed potassium channel ROMK1 to cause hyperkalemia, which rapamycin or Klotho supplementation reversed.