No phaseCompleted
Intermitent Hypoxia and Its Pathophysiology Consequences in the Sleep Apnea-Hypopnea Syndrome.
Intermitent Hypoxia and Its Pathophysiology Consequences in the Sleep Apnea-Hypopnea Syndrome. Basic, Clinical and Therapeutically Study.
- Sponsor
- Alberto Alonso Fernandez (Government)
- Enrolment
- 130 enrolled
- Conditions
- Sleep Apnea, Obstructive
- Interventions
- CPAP
- Ages
- adults, older adults
- Registry
- NCT04444778
Full record on ClinicalTrials.gov
From the registry
Clinical trial on the effect of continuous positive pressure (CPAP). Objectives: 1) To assess the total or partial recovery of oxidative and inflammatory damage after recovering IH. 2) To check whether the results obtained in vitro on the recovery of the damage according to the form of manifestation of IH are validated in SAHS patients. 3) To determine if CPAP reduces nighttime blood pressure and arterial stiffness depending on whether or not patients have a non-dipping pattern of blood pressure and depending on the degree of correction of IH. 4) To clarify whether residual nocturnal hypoxemia influences the recovery of oxidative and inflammatory damage in patients. 5) To determine nasal and intestinal microbioma and the effect of CPAP treatment
Primary outcomes
- Change from baseline in 8 isoprostane levels
- Change from baseline in microbiota population diversity from stool samples
- Change from baseline in microbiota population diversity from nasopharyngeal samples
- Change from baseline in microbiota population abundance from stool samples
History
Last registry update
Study completion
Primary completion
Started
Registered