Papers by Lei Li

16 results

  1. Frontiers in Immunology

    Fungus drives spleen aging in mice, eased by astragaloside IV

    In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune function and iron…In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune function and iron homeostasis.

    Experiments in miceInterventions
  2. Advanced Science

    Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice

    The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic…The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic deficits.

    Experiments in miceHuntington's disease