Papers by H. Chen

330 results

  1. Aging Cell

    Anti-aging clock results often fail across multiple models

    When researchers applied extra biological age clocks to previously tested anti-aging treatments, no additional clock showed a statistically meaningful effect.When researchers applied extra biological age clocks to previously tested anti-aging treatments, no additional clock showed a statistically meaningful effect.

    Computational studyBiomarkers
  2. Free Radical Biology & Medicine

    Two PDE4 inhibitors extend lifespan in worms

    In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated…In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated oxidative stress.

    Experiments in wormsInterventions
  3. AJNR American Journal of Neuroradiology

    Carotid stenting linked to more cognitive decline than surgery

    In asymptomatic carotid stenosis, five-year rates of cognitive decline or dementia were 18.06% after carotid stenting versus 15.24% after carotid endarterectomy.In asymptomatic carotid stenosis, five-year rates of cognitive decline or dementia were 18.06% after carotid stenting versus 15.24% after carotid endarterectomy.

    Cohort study in peopleInterventions