BiomarkersHumans2,915 participantsCross-sectional study

Menopause impact questionnaire validated in US women

A 22-question measure covering seven symptom areas was supported by three online studies of 2,915 US women aged 21–85.

Figure 1 from Maturitas
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Figure 1Kiss et al.

Maturitas

Three online observational studies involving 2,915 women aged 21–85 in the United States developed and tested a questionnaire measuring menopause-related symptom impact. Researchers first assessed 57 questions, then reduced the scale to 22. They tested its final structure in a separate group of 1,000 women.

The questionnaire covered seven areas: thinking, self-perception, sexual and vaginal symptoms, muscles and joints, hot flushes and related symptoms, sleep, and urinary symptoms. Both later studies supported this seven-part structure. Scores were strongly related to scores on an existing menopause symptom questionnaire and moderately related to burnout scores. Symptom impact scores peaked at ages 45–55.

Why it matters

Understanding how menopause-related symptoms affect life is part of studying health in midlife. The authors concluded that the scale could support research, clinical assessment and digital applications.

Caveats

Validation relied on online questionnaire responses and comparisons with other questionnaires. The studies did not test whether using the scale improved care.

The paper

A multidimensional, person-centered measure of menopausal symptom impact: Development and validation of the Menopause Impact Scale (MIS)