Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf-1/ERK1/2/PINK1 Signaling Axis

Abstract

Despite extensive research, the etiology of metabolic dysfunction-associated steatotic liver disease (MASLD) remains incompletely understood. Through analysis of single-cell RNA sequencing (scRNA-seq) data from murine and human MASLD models, we identify a lipid-associated hepatocyte population and implicate Rab1A as its prominent player.

The paper